Skip to content

News Health

Health News, Tips, and More

Menu
  • Disclaimer
  • Related Sites
Menu

A drugs with vitamin A may be useful for dry macular degeneration

Posted on December 28, 2010December 26, 2010 by News Health

You should be know that the vitamin A is more than good for the eyes, it’s neccessery for them. Some researchers have recently found this to be true when using a vitamin A-derived drug, fenretinide, to stop the advance of dry macular degeneration. They discovered that the most common form of this currently uncurable eye disease responds well to the drug.

Macular degeneration is eye disease which is really dangerous in aging, when it can destroys a person’s sharp, central vision. It is a leading cause of vision loss in Americans age 60 and older. In most cases the loss of vision is gradual. Approximately 2 million adults in the United States have macular degeneration.

Age-related macular degeneration affects the macula, which is located in the center of the retina. The disease can occur in one of two forms—dry or wet—with dry comprising 85 to 90 percent of cases. Dry macular degeneration is characterized by drusen, a yellow substance that accumulates under the retina, and the breakdown of light-sensitive cells in the eye.

The promising news about fenretinide was presented at the Annual Meeting of the American Academy of Ophthalmology in Chicago on October 17 by Jason Slakter, MD, of New York University School of Medicine. He explained how fenretinide, which has been used to treat acne, psoriasis, rheumatoid arthritis, and certain cancers, reduced the chance that dry macular degeneration would progress to wet AMD in more than 50 percent of some patients.

In healthy eyes, the body removes waste products that result from the metabolism of nutrients in the inner layers of the eye. When the clean-up system malfunctions, debris known as lipofuscin, along with vitamin A metabolites, accumulate in the eye and cause damage to the retina. Fenretinide attaches itself to a retinal binding protein and thus reduces the chance that toxic build-up and lesion growth will occur.

One hundred seventy-eight patients with dry macular degeneration were enrolled in a phase 2, double-blind, placebo-controlled, 24-month study that was conducted at 30 sites around the United States. Sixty-eight patients received placebo, 52 received 100 mg daily of fenretinide, and 58 received 300 mg of fenretinide. A total of 246 patients completed the study. Individuals who showed the greatest decline in the amount of retinal binding protein also had the least risk of dry macular degeneration or progression to the wet form of the disease.

At 24 months, 22 percent of patients taking placebo had developed wet macular degeneration compared with 13.5 percent of patients who had taken 100 mg of fenretinide and 13.8 percent who had taken 300 mg. Dr. Slakter noted that the drug formulation was changed mid-way through the study, and that nearly all of the treatment benefit was seen in patients who took the original form of the 300-mg dose.

3 thoughts on “A drugs with vitamin A may be useful for dry macular degeneration”

  1. Reita Stuller says:
    March 11, 2011 at 8:26 am

    Hi I’ve had constant acne since I was 12. My life is hard enough without having this. This week, after a nice rare clear skin period that lasted a week, I have broken out in severe acne. I haven’t changed my diet or started using anything new.

  2. Keurig K Cups says:
    May 25, 2011 at 10:11 pm

    Awesome site, keep up the good work… bookmarked!

  3. Iris EYe Gel Review says:
    October 12, 2013 at 1:53 am

    Marvelous, what a blog it is! This webpage gives helpful facts to
    us, keep it up.

Leave a Reply

Your email address will not be published. Required fields are marked *

Recent Posts

  • Dental Hygiene Made Easy With This Advice
  • Ways to Live Your Healthiest Life
  • Altering Your Home to Live With a Disability at 60
  • 10 Tips for Better Life Health and Wellness
  • Ways to Broaden and Improve Your Wellness Perspective
  • Do You Struggle to Focus on Your Mental Health? Tips for Creating Habits and Finding Hobbies for Yourself
  • What to Know About Bowel Endometriosis Surgery
  • How to Plan an Objective for Your Health and Fitness Event
  • Dental Hygiene Made Easy With This Advice
  • What to Expect During the First Week of Drug Rehab

Archives

September 2023
M T W T F S S
 123
45678910
11121314151617
18192021222324
252627282930  
« Aug    
© 2023 News Health | Powered by Superbs Personal Blog theme