Oliver J. Rando, MD, PhD, associate professor of biochemistry & molecular pharmacology at UMMS and principal investigator for the study says, that they explorer and receive that the parents were doing before you were conceived is turning out to be important in determining what disease risk factors you may be carrying. Scientists have been studying how genetic mutations and DNA changes make humans sick. Dr. Rando says that a major and underappreciated aspect of what is transmitted from parent to child is ancestral environment. Offspring of the male mice given a low protein diet were found to have chances consistent with past studies linking paternal diet to epigenetic changes in the next generation.
They specifically found offspring of males fed low protein diet had increased lipid and cholesterol synthesis. One such study performed retrospectively on a Swedish population called the Överkalix Cohort Study, hinted that what a grandfather ate could lead to diabetes, obesity and cardiovascular disease in second-generation offspring. According to Rando, Our study begins to rule out the possibility that social and economic factors, or differences in the DNA sequence, may be contributing to what we’re seeing. It strongly implicates epigenetic inheritance as a contributing factor to changes in gene function.”
Hans A. Hofmann, PhD, associate professor of integrative biology at the University of Texas at Austin and a co-author of the study says, “It has increasingly become clear in recent years that mothers can endow their offspring with information about the environment, for instance via early experience and maternal factors, and thus make them possibly better adapted to environmental change. Our results show that offspring can inherit such acquired characters even from a parent they have never directly interacted with, which provides a novel mechanism through which natural selection could act in the course of evolution.” The findings from the study show it may be important to understand what parents eat when assessing for individual disease risk factors, and not just a person’s lifestyle. The researchers say they’re not certain how what your father ate transmits good or bad health, but they plan to explore how genetic information is passed from father to offspring and from mother to future generations.