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For children with Polychlorinated Biphenyls

Posted on June 22, 2010June 21, 2010 by News Health

Children exposed to polychlorinated biphenyls (PCBs) early in life later had a diminished immune response to diphtheria and tetanus vaccinations, according to a study published online June 20 ahead of print in the peer-reviewed journal Environmental Health Perspectives (EHP). This result suggests that PCB exposure during the first years of life, a critical period in immune system development, could undermine the effectiveness of childhood vaccinations and possibly impair immune system responses to infection.

PCBs are long-lived environmental contaminants that are suspected to be toxic to the immune system. The study included 587 children born between 1999 and 2001 who lived in the Faroe Islands. The residents of the Faroe Islands, which lie midway between Norway and Iceland in the North Atlantic, have widely varying PCB exposure due to differing consumption patterns of contaminated traditional foods such as pilot whale blubber. Routine childhood vaccinations, which feature standard antigen doses at set time points, provided an opportunity to examine immune responses in the Faroese children.

Mothers provided blood samples at 32 weeks of pregnancy and milk samples 4 to 5 days after birth. Children received vaccinations against diphtheria and tetanus at 3, 5, and 12 months and booster vaccinations at 5 years. Blood samples were collected from children at 12 or 18 months, before and after vaccinations at age 5, and again at age 7. The mothers’ samples were analyzed for PCB content, and the children’s samples were tested for PCBs and/or diphtheria and tetanus antibody concentrations.

Higher PCB concentrations, particularly in children at 18 months, were associated with lower concentrations of antibodies against diphtheria and tetanus at ages 5 and 7. In some cases, children’s antibody concentrations were below levels needed to protect against the two diseases. Elements of the immune system critical to its response to antigens undergo crucial development during the toddler years. Adverse impacts at this stage could have consequences beyond the diseases specific to this study. These findings may also have implications for other environmental chemicals with toxic effects on the immune system.

Authors of the paper were Carsten Heilmann, Esben Budtz-Jørgensen, Flemming Nielsen, Birger Heinzow, Pál Weihe, and Philippe Grandjean. Support was provided by the Danish Environmental Protection Agency, the Danish Council for Strategic Research, the U.S. Environmental Protection Agency, and the National Institute of Environmental Health Sciences.

source:   http://www.medicalnewstoday.com/articles/192387.php

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